K. BRIDGET BROSNIHAN, Ph.D.
Professor Surgical Sciences; Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Department of Obstetrics and Gynecology, Section of Molecular Medicine, Neuroscience Program. Director of the Hypertension Core Laboratory. Co-Director of the Molecular Medicine Graduate Program.
Hanes Building – 6th floor
Medical Center Boulevard
Winston-Salem, NC 27157-1032
Tel: 336-716-2795
Fax: 336-716-2456
Email: bbrosnih@wfubmc.edu
Education:
College of St. Mary, BS, 1965
Creighton University, MS, 1970
Case Western Reserve University Medical School, PhD, 1974
Research Description:
Neuroendocrine aspects of hypertension
Vascular biology
Pregnancy and hormone replacement
Current Research:
Her laboratory studies the role of hormones in the control of blood pressure and vascular reactivity. She uses physiological and pharmacological approaches to study cardiovascular and hormonal consequences of pregnancy and the role of estrogen. Biochemical methods allow the measurement of tissue and circulating levels of neuroendocrine hormones. Research approaches in her laboratory study the mechanism of synthesis and secretion of angiotensin peptides from a number of local tissues. Dr. Brosnihan has published over 18 chapters and 100 manuscripts. She has maintained an uninterrupted record of funding from the National Heart, Lung, and Blood Institute of the NIH from 1984.
Recent Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.
Pendergrass KD, Pirro NT, Westwood BM, Ferrario CM, Brosnihan KB, Chappell MC. Sex differences in circulating and renal angiotensins of hypertensive mRen(2).Lewis but not normotensive Lewis rats. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H10-20.
Brosnihan KB, Li P, Figueroa JP, Ganten D, Ferrario CM. Estrogen, nitric oxide, and hypertension differentially modulate agonist-induced contractile responses in female transgenic (mRen2)27 hypertensive rats. Am J Physiol Heart Circ Physiol. 2008 May;294(5):H1995-2001.
Anton L, Merrill DC, Neves LA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia. Hypertension. 2008 Apr;51(4):1066-72.
Schindler C, Ferrario CM, Jatzke C, Ahner K, Brosnihan KB, Bramlage P, Maywald U, Oertel R, Boecking W, Kirch W. Characterization of vascular reactivity in dorsal hand veins after oral rosiglitazone treatment in healthy subjects. Int J Clin Pharmacol Ther. 2008 Jan;46(1):30-9.
Brosnihan KB, Hodgin JB, Smithies O, Maeda N, Gallagher P. Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice. Exp Physiol. 2008 May;93(5):658-64.