Patrick Rowe, Ph.D.

Postdoctoral Fellow

Dept. of Pathology, Immunology and Laboratory Medicine
University of Florida College of Medicine

Education:

Ph,D., Molecular Medicine, 2001 – 2007
Wake Forest University, Winston-Salem, NC

B.S., Biology, 1996 – 2000

Virginia Tech, Blacksburg, VA

Research Interests:  

My research interests deal with the immunology of type 1 diabetes and, specifically, ways to reestablish tolerance to self-antigens.  As a number of strategies are being explored to replace beta cell mass in diabetic individuals, the need for interventions that reverse autoimmunity as well as prevent rejection of transplanted islets and cells without serious side effects is a significant obstacle to curing type 1 diabetes.  Tolerance induction has the potential to meet this need and, thereby, prevent destruction of beta cells at onset, allow for endogenous regeneration of beta cells, enable the use of stem cell-derived beta cells, and engender the more widespread application of islet transplantation.   

Publications:

P.A. Rowe, L. Zhang, K. Kavanagh, P.V. Katakam, D.W. Busija, and J.D. Wagner. Effects of Short-term Hyperglycemia on Arterial Oxidative Stress: Interaction between Superoxide Anion Production and Iron Dysregulation. (in preparation)

Grants:

Cross-Campus Collaborative Research Support Fund. Wake Forest University. 

Effects of short-term hyperglycemia on arterial and liver redox-active iron concentrations.  J.D. Wagner, D.V.M., Ph.D.and D.B. Kim-Shapiro, Ph.D.  4/2006-4/2007