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Jacquelyn S. Fetrow, Ph.D.
Reynolds Professor of Computational Biophysics
Dean of the College of Arts and Sciences, Departments of Physics and Computer Science
Email: fetrowjs@wfu.edu
Education:
B.S. Biochemistry, May 1982, Albright College , Reading PA
Ph.D. Biological Chemistry, December 1986, Pennsylvania State University College of Medicine, Hershey, PA
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Research Interests:
Research in the Fetrow Laboratory is focused on understanding the relationships between the structures, functions and dynamic motions of protein molecules. We are interested in understanding both the functions of protein molecules and how proteins interact in signaling and other types of cellular networks. Our long term goal is to identify computational methods that will enhance our understanding the disease mechanisms and accelerate the structure-based drug discovery process.
Current Research:
Current projects include:
- Identifying transcriptional regulatory networks underlying osteoarthritis. (Collaboration with Richard Loeser, funded by the Arthritis Foundation)
- Modeling of signal transduction pathways, particularly redox signaling pathways. (Collaboration with Cristina Furdui, Leslie Poole, Larry Daniel, and others; funded by the NIH)
- Identifying and modeling signaling networks in plants, in response to auxin and ethylene (Collaboration with Gloria Muday and researchers at Virginia Tech; funded by the NSF)
- Identifying and predicting molecular functional sites in redox-related protein families (Collaboration with Leslie Poole, William Turkett, and Freddie Salsbury and researchers at UCSF)
A unifying element among these projects is the computational tools that we are continually developing and implementing, including databases for rapid retrieval of information about protein functional sites, computational algebraic and Bayesian methods for analyzing systems biology, and electrostatic analysis across molecular dynamics simulations. Our research is highly interdisciplinary—each project includes collaborations with researchers at Wake Forest University School of Medicine, UCSF, Virginia Tech, UNC-Chapel Hill, and other institutions. For more information, see our laboratory web site.
Recent Publications:
1. Salsbury Jr., F.R., Knutson, S.T., Poole, LB, and Fetrow, J.S. Functional Site Profiling and Electrostatic Analysis of Cysteines Modifiable to Cysteine Sulfenic Acid. Protein Sci. 2008 Feb;17(2):299-312.
2. Poole, LB, Klomsiri, C, Knaggs, SA, Furdui, CM, Nelson, KJ, Thomas, MJ, Fetrow, JS, Daniel, LW, and King, SB. Fluorescent and Affinity-Based Tools To Detect Cysteine Sulfenic Acid Formation in Proteins. Bioconjugate Chem. 2007 Nov-Dec;18(6):2004-17. Epub 2007 Nov 21.
3. Michalek R.D., Nelson K.J., Holbrook B.C., Yi J.S., Stridiron D., Daniel L.W., Fetrow J.S., King S.B., Poole L.B., Grayson J.M. The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. J Immunol. 2007 Nov 15;179(10):6456-67.
4. Budiman, M.E., Knaggs, M.H., Fetrow, J.S., and Alexander, R.W. Using molecular dynamics to map interaction networks in an aminoacyl-tRNA synthetase. Proteins: Struct Funct Bioinform. 2007 Aug 15;68(3):670-89.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine
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