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Research Description:
Biochemical and molecular aspects of the renin-angiotensin system Gender differences in renal and cardiac injury Role of estrogen in the development of salt-sensitive hypertension
Current Research:
His laboratory studies the role of the renin-angiotensin system in the regulation of blood pressure and the development of salt-dependent hypertension and tissue organ injury. The laboratory utilizes a multidisciplinary approach encompassing transgenic animal models, isolated tissue systems and primary and established cell lines to facilitate characterization of peptide hormones, their receptor proteins and the associated cell signaling pathways. Current areas of research focus on the marked gender differences in the development of hypertension and renal injury. Dr. Chappell has published 7 book chapters, 65 manuscripts and over 100 abstracts concerning various aspects of the cardiovascular system. He receives current funding from the National Heart, Lung, and Blood Institute of the NIH and the American Heart Association.
Recent Publications:
Trask AJ, Averill DB, Ganten D, Chappell MC, Ferrario CM. Primary Role of Angiotensin Converting Enzyme 2 in Cardiac Production of Angiotensin-(1-7) in Transgenic Ren-2 Hypertensive Rats. Am J Physiol Heart Circ Physiol. 2007 Feb 16
Yamaleyeva LM, Gallagher PE, Vinsant S, Chappell MC. Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R819-26. Epub 2006 Oct 5.
Shaltout HA, Westwood B, Averill DB, Ferrario CM, Figueroa J, Diz DI, Rose JC, Chappell MC. Angiotensin Metabolism in Renal Proximal Tubules, Urine and Serum of Sheep: Evidence for ACE2-Dependent Processing of Angiotensin II. Am J Physiol Renal Physiol. 2006 Aug 8.
Neves LA, Chappell MC, Ferrario CM, Gallagher PE, Ganten D, Brosnihan KB. Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats. Peptides. 2006 Aug 3.
Chappell MC, Yamaleyeva LM, Westwood BM. Estrogen and Salt-Senstivity in the Female mRen(2).Lewis Rat. Am J Physiol Regul Integr Comp Physiol. 2006 Jul 6.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine |