Stephen S. Rich, PhD

Professor and Vice Chair, Department of Public Health Sciences – Section on Administration; Professor, Neurology; Associate Professor, Cancer Biology

Email: srich@wfubmc.edu

Education:

North Carolina State University, BS, 1973

Purdue University, MS, 1975

Purdue University, PhD, 1979

Research Interests:

Genetic epidemiology of complex human disease

Current Research:

We are researching the basic mechanisms that predispose to, and protect from, common disease in humans using a combination of statistical genetic and genetic epidemiological approaches. From this information, we are evaluating the impact of genetically inherited surrogate markers for the development of disease that precedes actual disease onset. In this fashion, we can investigate ways of modulating or preventing the development of the disease process in genetically susceptible individuals as part of a rational approach to the prevention of common disease, including the genetic basis of type 1 diabetes, type 2 diabetes and its complications (micro- and macro-vascular disease), and stroke.

Recent Publications:

Leak TS, Keene KL, Langefeld CD, Gallagher CJ, Mychaleckyj JC, Freedman BI, Bowden DW, Rich SS, Sale MM. Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population. Mol Genet Metab. 2007 Jul 5.

Sale MM, Smith SG, Mychaleckyj JC, Keene KL, Langefeld CD, Leak TS, Hicks PJ, Bowden DW, Rich SS, Freedman BI. Variants of the Transcription Factor 7-Like 2 (TCF7L2) Gene are Associated with Type 2 Diabetes in an African American Population Enriched for Nephropathy. Diabetes. 2007 Jun 29.

Acton RT, Snively BM, Barton JC, McLaren CE, Adams PC, Rich SS, Eckfeldt JH, Press RD, Sholinsky P, Leiendecker-Foster C, McLaren GD, Speechley MR, Harris EL, Dawkins FW, Gordeuk VR; Hemochromatosis and Iron Overload Screening Study Research Investigators. A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study. Clin Genet. 2007 Jun;71(6):518-29.  

Matarin M, Brown WM, Hardy JA, Rich SS, Singleton AB, Brown RD Jr, Brott TG, Worrall BB, Meschia JF. Association of integrin alpha2 gene variants with ischemic stroke. J Cereb Blood Flow Metab. 2007 May 30.

Gallagher CJ, Langefeld CD, Gordon CJ, Campbell JK, Mychaleckyj JC, Bryer-Ash M, Rich SS, Bowden DW, Sale MM. Association of the Estrogen Receptor Alpha gene with the Metabolic Syndrome and its component traits in African American families: The IRAS Family Study. Diabetes. 2007 May 18.

Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine