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Molecular Medicine Graduate Degree Programs

Amanda Brown

Fifth Year Student: 2009 - 2010

Email address: amabrown@wfubmc.edu

Education:

Ohio Wesleyan University, B.A. 2005
Majors: Microbiology and Genetics
Minor: Chemistry

Advisor: John S. Parks, Ph.D.: Pathology (Lipid Sciences)

 

Current Research:

 

Understanding the molecular mechanisms by which omega-3 fatty acid enriched oil, derived from Echium plantagineum, reduces plasma triglyceride concentrations and whether supplementation with echium oil will reduce atherosclerosis and arterial inflammation to a degree similar to that observed with fish oil.  My research is aimed at how this botanical oil affects the activation state of macrophages elicited from mice fed supplementation diets and whether supplementation will lead to changes in expression of genes involved in inflammation as has been evidenced in fish oil studies.

Academic and Professional Honors:

2001-2002      ranklin B. Walter Award, one senior from each county in Ohio recognized by the OESCA

2001-2002      Sam Walton Community Scholarship

2001-2005      Leland F. and Helen Schubert Honors Program, Ohio Wesleyan University

2001-2005      Ohio Wesleyan University Trustee Scholarship covering three-quarters
                     of the cost of tuition

2004-2005      Member of the American Society of Plant Biologists

2005              Graduated with Honors, Cum Laude, Ohio Wesleyan University

2005              Esther Carpenter Award for a senior female who has shown exemplary academic and research achievement in the Department of Botany-Microbiology, Ohio Wesleyan University

2005-2008       Graduate Fellowship Award, Wake Forest University School of Medicine

2008-Present   Student Member of the American Heart Association

2008-Present   Ruth L. Kirschstein National Research Service Award

Publications:

Journal Articles:

Mulya A, Brown AL, Chung SK, Seo J, Gebre AK, Boudyguina E, Shelness GS, Parks JS.  Apolipoprotein M (apoM) expression increases the size of nascent pre-beta (pre-β) HDL formed by ATP Binding Cassette Transporter A1 (ABCA1). Journal of Lipid Research [In revision]

Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong MN, Brown AL, Shah R, Davis M, Kelley K, Wilson M, Parks JS, Rudel LL.

Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 (SCD1) Inhibition Prevents The Metabolic Syndrome and Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology [In revision]

Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong MN, Wibley AL, Shah R, Davis MA, Kelley K, Wilson MD, Kent C, Parks JS, Rudel LL.

Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation. 2008 Sep 30;118(14):1467-75.

Abstracts:

Brown AL, Zhu XW, Wilson MD, Alexander-Miller  M, Parks JS. Echium Oil Promotes Phenotypic Shifting in the Macrophage Lineage. Arteriosclerosis, Thrombosis, and Vascular Biology 29(7): E24 JUL  2009

Wibley AL, Beauchamp N, Wilson MD, Alexander-Miller  M, Parks JS.

Echium Oil Modifies Macrophage Phenotypic Switching. NCCAM Botanical Center Directors’ Meeting, MAY 2008

Brown, JM Chung SK, Alger HM, Sawyer JK, Degirolamo C, Nguyen T, Zhu XW, Duong MN, Wibley AL, Davis MA, Kelley K, Wilson MD, Parks JS, Rudel LL. Inhibition of stearoyl-CoA desaturase 1 (SCD1) dissociates insulin resistance and obesity from atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 28(6):  E93 JUN  2008

Mulya A, Wilbley A, Chung SK, Gebre AK, Shelness GS, Parks JS. Impact of apolipoprotein M expression on pre-beta HDL formation by ATP binding cassette transporter A1 (ABCA1). Arteriosclerosis Thrombosis and Vascular Biology 27(6): E36 JUN 2007 

Polter A, Wibley A, Mullen JL, Wolverton C.  Gravitropism in akt1-1 roots lacks a significant DEZ contribution. American Society Plant Biologists P50: Abs# 415 JUL 2004