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Research Interest:
I studied the interactions of certain phospholipids with the flavocytochrome b558 component of NADPH oxidase in human neutrophils. Certain protein defects in NADPH oxidase have been linked to Chronic Granulomous Disease which involved the inability of the body to clear certain types of infection. My research is involved in this method of clearance.
Publications:
Singla M, Lewis EM, Sergeant S, Koty PP, McPhail LC. "X-Linked Chronic Granulomatous Disease Presenting in a 16-Year-Old Female Secondary to Skewed X Chromosome Inactivation." Abstract presented at the Annual Meeting of the American Academy of Allergy, Asthma, and Immunology in San Antonio, TX, 2005.
Lewis EM, Ledford B, Taylor AJ, Jesaitis AJ, McPhail LC. "A Novel Assay Detects Phosphatidic Acid Binding to Flavocytochrome b558 of the NADPH Oxidase Complex." Oral presentation given at the 39th Annual Southeastern Regional Lipid Conference in Cashiers, NC, 2004.
"Neutrophil Killing in Innate Immunity." Lecture presented in Fundamentals of Immunology (MICRO 705)
"Neutrophil Dysfunction and Disease." Lecture presented in Molecular Basis of Human Disease I (MOME 721)
Awards:
Biochemical Journal Young Investigator Award. 39th Annual Southeastern Regional Lipid Conference. Cashiers, NC, 2004.
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