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Research Interests:
Dr Sandeep Mannava comes to the Physician Scientist Program at the Wake Forest University Department of Orthopaedic Surgery and the Molecular Medicine and Translational Sciences graduate school program with a strong background in biophysics and physiology. Since arriving at Wake Forest, he has worked closely with the Orthopaedic Surgery Tissue Engineering Group to build upon their previous work in order to address the problem of rotator cuff tears, a common cause of upper extremity pain and disability. Dr Mannava is investigating the potential of a novel, naturally-derived scaffold in reconstructing large rotator cuff tears. The naturally derived and biocompatible graft under investigation has reduced immunogenicity, sufficient host integration, and adequate mechanical strength. Dr. Mannava’s goal is to use this graft—that has been successfully applied to other clinical orthopaedic applications—to bridge the large gap created after a rotator cuff tear and muscle atrophy. This research will be the basis of his Ph.D. thesis. Further, this project expands the Orthopaedic Surgery Department’s regenerative medicine and tissue engineering program. He is optimistic that tissue engineering techniques can be used to improve the healing and remodeling potential of the torn rotator cuff, which currently has no gold-standard surgical treatment that successfully restores pre-injury strength, range of motion, and function.
Publications:
Characterization of multiple spiral wave dynamics as a stochastic predator-prey system. Otani NF, Mo A, Mannava S, Fenton FH, Cherry EM, Luther S, Gilmour RF Jr. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Aug;78(2 Pt 1):021913. Epub 2008 Aug 29.PMID: 18850871
Transmembrane action potential heterogeneity in the canine isolated arterially perfused right atrium: effect of IKr and IKur/Ito block. Burashnikov A, Mannava S, Antzelevitch C. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2393-400. PMID: 15148061
Mannava S, Otani NF, and Gilmour RF. (2005). The Predator-Prey Relationship in 2D Spiral Wave Simulations. Cornell University Undergraduate Honors Thesis.
Awards:
· Howard Hughes Research Scholarship (Summer 2004)
· American Heart Association Award (Summer 2004)
· Masonic Medical Research Laboratory Summer Fellowship (Summers 2002 and 2003)
Research Experience:
· State University of New York at Syracuse—Upstate Medical University, Department of Pharmacology, Research Assistant (2006-2007)
· Cornell University, Department of Biomedical Sciences, Research Assistant (2004-2005)
· Weill Cornell Medical School, Department of Physiology and Biophysics, Urban Semester Student (Fall 2003)
· Masonic Medical Research Laboratory, Department of Experimental Cardiology, Summer Research Fellow (2002-2003)
Research Lab: 2009-2011
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