Revati Wani         

Third Year Student, 2009 - 2010

Email address: rwani@wfubmc.edu

Education:

MS (Biochemistry), 2006, University of Pune, India

BS (Chemistry) 2004, University of Pune, India

Advisor: Cristina M. Furdui, Ph.D.:

Internal Medicine (Molecular Medicine)

Current Research:

My current research involves investigation of the role of post-translational modifications such as oxidation and phosphorylation on regulating growth factor mediated intracellular signaling following a proteomics approach utilizing high throughput techniques such as mass spectrometry. More specifically, the interest is in investigating the effect of oxidation on phosphorylation of signaling kinases and its impact on downstream molecular signaling. Understanding these oxidative modifications is of critical significance in explaining the signaling perturbations underlying ‘oxidative pathogenesis’ of several clinical conditions such as atherosclerosis and cancer.

Honors and Awards:

2006:   Junior Research Fellowship Award: Indian Council of Medical Research

Professional Society Membership(s):

American Society for Mass Spectrometry (ASMS)

Publications:

Manuscripts

Wani R, Kodam KM, Gawai KR, Dhakephalkar PK. Chromate reduction by Burkholderia cepacia MCMB-821 isolated from the pristine habitat of alkaline crater lake. Applied Microbiology Biotechnology (2007) 75:627-632        

Abstracts:

Revati Wani, Allen W. Tsang, Cristina M. Furdui, et.al. High-Throughput Identification of S-Oxidized Proteome and Effect of Oxidation on Modulating Akt2 activity; 9^th Annual Graduate Student Research Day, Winston-Salem, April 2009

Leslie B.Poole, Chananat klomsiri, Kimberly J. Nelson, Revati Wani, Allen W. Tsang, Cristina M. Furdui, et.al; Protein Sulfenic acid detection and mapping in biological samples; Federation of European Biochemical Societies (FEBS) Advanced Lecture Course on Mechanisms and Consequences of Free Radical-Mediated Oxidative Protein Modifications, Turkey,  April 2009

Revati Wani, Allen W. Tsang, Chananat Klomsiri, Bruce S. King, Leslie Poole, Cristina M. Furdui;  Identification of Sulfenated Proteome using a Biotin-tagged sulfenic acid-specific reagent DCP-Bio1; JASMS, Abstract No. 2136; 56^th American Society for Mass Spectrometry Conference on Mass Spectrometry,  Denver, June 2008

Allen W. Tsang, Revati Wani, Cristina M. Furdui; Proteomics Analysis of early Signaling events in response to ordered tyrosine phosphorylation in PDGFR; JASMS, Abstract No. 2909;  56^th American Society for Mass Spectrometry Conference on Mass Spectrometry,  Denver, June 2008