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Research Interests:
Epigenetic regulation of gene reprogramming in severe systemic inflammation
Current Research:
Gene reprogramming in serve systemic inflammation generates silencing of acute proinflammatory genes without changes in anti-inflammatory gene expression. Epigenetic studies have demonstrated that NF-kB family proteins interplay with the proximal promoters of genes to regulate innate immunity and inflammation. My current research is focused on understanding (1) how posttranslational modifications of NF-kB family proteins regulate acute inflammatory gene expression in severe systemic inflammation; and (2) the biochemical requirements for protein-protein interactions involved in the regulation of gene remodeling in severe systemic inflammation.
Recent Publications:
T. F. Liu, J. Cai, D. M. Gibo and W. Debinski. Reoxygenation of Hypoxic Glioblastoma Multiforme Cells Potentiates the Killing Effect of an IL-13 based Cytotoxin. Clin Cancer Res. 2009 Jan 1;15(1):160-8.
T. F. Liu, K. A. Cohen, M. C. Willingham, J. Cai, A. Thorbun and A. E. Frankel. Interstitial Diphtheria toxin-epidermal growth fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice. Clinical Cancer Research, 11(1):329-34, 2005
T. F. Liu, J. O Urieto, M. S. Miller, A. Thorburn J. Thorburn, J. S. Richardson, D. C. Richardson and A. E. Frankel. Diphthera toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicity. Experimental Hematology, 32(3), 277-281, 2004
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine |