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Research Interests:
S100 proteins in Osteoarthritis
Current Research:
S100 proteins constitute one of the largest groups in the EF-hand calcium-binding protein family and are implicated in various cellular functions. Members of this family are known to exhibit cell and tissue specific expression and up regulated in various human pathologies. My research is focused on understanding the function and regulation of S100A4 in chondrocytes and its role in development of osteoarthritis (OA). Recent work has focused on the cell signaling pathways activated by S100A4 which regulate the expression of matrix-metalloproteinase (MMP).
Recent Publications:
1. Yammani RR, Long DL, Loeser RF (2008) Interleukin-7 Stimulates Secretion of S100A4 by Activating the JAK-STAT Signaling Pathway in Human Articular Chondrocytes. Arthritis Rheum. 2009;60(3):792-800.
2. Cravero JD, Carlson CS, Hee-Jeong-Sampen, Yammani RR, Long DL, Loeser RF (2008) Increased Expression of the Akt/PKB Inhibitor TRB3 in Osteoarthritic Chondrocytes Inhibits IGF-1 Mediated Cell Survival and Proteoglycan Synthesis. Arthritis Rheum. Arthritis Rheum.2009:60(2):492-500.
Yammani RR, Carlson CS, Bresnick AR, Loeser RF. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum. 2006 Sep;54(9):2901-11.
Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, Bursch LS, Yan SD. Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum. 2005 Aug;52(8):2376-85.
Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.
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