Publications 1993-2003

Center for the Neurobiological Investigation of Drug Abuse
Wake Forest University School of Medicine
DA-06634

1993

Davies H. M. L. Tandem Cyclopropanation/Cope Rearrangement: A General Method for the Construction of Seven-Membered Rings. Tetrahedron, 1993, 49, 5203.

1994

Carelli RM, Deadwyler SA. A comparison of nucleus accumbens neuronal firing patterns during cocaine self-administration and water reinforcement in rats. J Neurosci 1994; 14(12): 7735-7746.

Davies HML, Matasi JJ. Rhodium(II) Catalyzed Intramolecular Reactions Between Vinyldiazomethanes and Pyrroles. Novel Synthesis of Fused 7-Azabicyclo[4.2.0]octadienes. Tetrahedron Lett, 1994; 35:5209.

Davies HML, Saikali E, Huby NSJ, Gilliat VJ, Matasi J, Sexton T and Childers SR. Synthesis of novel 2-substituted cocaine analogs and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex. J Med Chem, 1994; 37:1262-1268.

Porrino LJ, Migliarese K, Davies HML, Saikali E and Childers SR. Behavioral effects of the novel tropane analog, 2?-propanoyl-3?-(4-tolyl)tropane (PTT). Life Sciences, 1994; 54:PL 511-517.

1995

Bennett B A, Wichems CH, Hollingsworth C K, Davies HML, Thornley C, Sexton T and Childers SR. Novel 2-Substituted Cocaine Analogs: Uptake and Ligand Binding Studies at Dopamine, Serotonin and Norepinephrine Transport Sites in the Rat Brain. J Pharmacol Exp Ther, 1995; 272:1176.

Bennett BA, Hyde CE, Davies HML, Sexton T and Childers SR. Correlation of uptake and binding potencies for novel tropane analogs at dopamine, serotonin, and norepinephrine transporters in rat brain membranes and synaptosomes. J Pharmacol Exp Ther 1995; 272:1176-1186.

Carelli RM, Deadwyler SA. Role of conditioning in the phasic firing patterns of nucleus accumbens neurons exhibited during cocaine self-administration in rats. NIDA Res. Monogr. 1995; 153:248.

Davies HML, Matasi J, Thornley C. Control of Carbenoid Reactivity Through Neighboring Group Participation. Tetrahedron Lett, 1995; 36:7205.

Davies HML. Reaction of Metal Stabilized Carbenoids with Pyrroles. Advances in Heterocycles, by JAI Press Inc, 1995; 1:1-18.

Dworkin SI, Mirkis S, Smith JE. Response-dependent versus response-independent presentation of cocaine: differences in the lethal effects of the drug. Psychopharmacol, 1995; 117:262-266.

Dworkin SI, Co C, Smith JE. Rat brain neurotransmitter turnover rates altered during withdrawal from chronic cocaine administration. Brain Res 1995; 682:116-126.

Dworkin SI, Mirkis S, Smith JE. Response dependent versus response independent presentation of cocaine: differences in the lethal effects of the drug. Psychopharmacol 117:257-261, 1995.

Hemby SE, Co C, Reboussin D, Davies HML, Dworkin SI, Smith JE. Comparison of a Novel Tropane Analog of Cocaine, 2?-Propanoyl-3?-(4-tolyl)tropane (PTT) with Cocaine HCl in Rats: Nucleus Accumbens Extracellular Dopamine Concentration and Motor Activity. J Pharmacol Exp Ther, 1995; 272:656.

Hemby SE, Martin TJ, Co C, Dworkin SI, Smith JE. The effects of intravenous heroin self- administration on extracellular nucleus accumbens dopamine concentrations determined by in vivo microdialysis. J Pharmacol Exp Ther, 1995; 273:591-598.

Hemby SE, Co C, Davies HML, Dworkin SI, Smith JE. Comparison of a novel tropane analog of cocaine 2 ?-propanolyl-d ?-(4-TOLYL) tropane (PTT) with cocaine HCl in rats: Nucleus accumbens extracellular dopamine concentration and motor activity. J Pharmacol Exp Ther, 1995; 273:656-666.

Kluttz B, Vrana KE, Dworkin S and Childers SR. Effects of morphine on forskolin-stimulated pro-enkephalin mRNA levels in rat striatum: a model for acute and chronic opioid actions in brain. Molec Brain Res, 1995; 32:313-320.

Martin TJ, Dworkin SI, Smith JE. Alkylation of ì-opioid receptors by ?-funaltrexamine in vivo: Correlation of the effects on the in situ binding and heroin self-administration in rats. J Pharmacol Exp Ther, 1995; 272:1135-1140.

Porrino LJ, Davies HML, Childers SR. Behavioral and Local Cerebral Metabolic Effects of the Novel Tropane Analog, 2?-Propoanoyl-3?-(4-tolyl)tropane (PTT). J Pharmacol Exp Ther 1995; 272:901

Vrana SL, Kluttz BW, Vrana KE. Application of quantitative RT-PCR to the analysis of D2 dopamine receptor mRNA. Mol Brain Res, 1995; 34:127-134.

1996

Carelli RM, Deadwyler SA. Dual factors controlling the activity of nucleus accumbens cell firing during cocaine self-administration. Synapse 1996; 24:308-311.

Carelli RM, Deadwyler SA. Dose-dependent transitions in nucleus accumbens cell firing and behavioral responding during cocaine self-administration sessions in rats. J Pharmacol Exp Ther 1996; 277:385-393.

Davies HML, Matasi JJ, Ahmed G. Divergent Pathways in the Intramolecular Reactions Between Rhodium-Stabilized Vinylcarbenoids and Pyrroles: Construction of Fused Tropanes and 7-Azabicyclo[4.2.0]octadienes. J Org Chem, 1996; 61:2305.

Davies HML, Kuhn L, Thornley C, Matasi JJ, Sexton T, and Childers SR. Synthesis of 3?-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transport site. J Med Chem, 1996; 39:2554-2558.

Davies HML, Ahmed G, Churchill MR. Asymmetric Synthesis of Highly Functionalized 8-Oxabicyclo[3.2.1]octane Derivatives. J Am Chem Soc, 1996; 118:10774.

Freeman WM, Vrana SL, Vrana KE. The use of elevated reverse transcriptase reaction temperatures in RT-PCR reactions. BioTechniques, 1996; 20:782-783.

Hemby SE, Smith JE, Dworkin SI. The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats. J Pharmacol Exp Ther 1996; 277:1247-1258.

Kumer SC, Vrana KE. The intricate regulation of tyrosine hydroxylase activity and gene expression. J Neurochem, 1996; 67:443-462.

Martin TJ, Walker LE, Sizemore GM, Smith JE, Dworkin SI. Within-session determination of dose-response curves for heroin self-administration in rats: Comparison with between-session determination and effects of naltrexone. Drug & Alcohol Depend, 1996; 41:93-100.

Sim LJ, Selley DE, Dworkin SI and Childers SR. Effects of chronic morphine administration on mu opioid-stimulated [35S]GTP?S autoradiography in rat brain. J Neurosci, 1996; 16:2684-2692.

Vrana KE. Advancing technologies in gene amplification. Trends in Biotechnology, 1996; 14:413-415.

1997

Carelli RM, Deadwyler SA. Cellular mechanisms underlying reinforcement-related processing in the nucleus accumbens: Electrophysiological studies in behaving animals. Pharmacol Biochem Behav 1997; 57:495-504.

Daunais JB, Hart SL, -Rowe AH, Thornley C, Matasi JJ, Davies HML, Porrino LJ. Alterations in Behavior and Opioid Gene Expression Induced by the Novel Cocaine Analog WF-31. Molecular Brain Res 1997; 50: 293-304.

Davies, H. M. L. Asymmetric Synthesis Using Rhodium-Stabilized Vinylcarbenoid Intermediates. Aldrichimica Acta, invited review article, 1997, 30, 105. (add to WEB)

Davies HML, Matasi JJ, Hodges LM, Huby NJS, Thornley C, Kong N. Practical Enantioselective Synthesis of Functionalized Tropanes By Rhodium(II) Carboxylate Catalyzed Decomposition of Vinyldiazomethanes in the Presence of Pyrroles. J Org Chem, 1997; 62:1095.

Hemby, S.E., Co, C., Koves, T.R., Smith, J.E., Dworkin, S.I. Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacol. 133;7-16, 1997.

Hemby SE, Lucki I, Gatto, G, Singh A, Thornley C, Matasi JJ, Kong N, Smith JE, Davies HML, Dworkin SI. Potential Antidepressant Effects of Novel Tropane Compounds, Selective for Serotonin or Dopamine Transporters. J Pharmacol Exp Ther, 1997; 282:727.

Letchworth SR, Hedgecock AA, Porrino LJ. Effects of chronic cocaine administration on dopamine transporter mRNA and accompanying protein expression in the rat. Brain Res 1997; 750: 214-222.

Lyons DH, Letchworth R, Daunais JB, Porrino LJ. Structural and functional brain imaging. In: Bankole JA, Roache J, eds, Drug Addiction and Its Treatment: Nexus of Neuroscience and Behavior. New York: Raven Press, 1997, pp 277-293.

Lyons D, Porrino LJ. Dopamine depletion in the rostral nucleus accumbens alters the cerebral metabolic response to cocaine in the rat. Brain Res 1997; 753:69-79.

Martin TJ, Miller M, Jr, Dworkin SI, Smith JE, Porrino LJ. Alteration of local cerebral glucose utilization following intravenous administration of heroin in Fischer 344 rats. Brain Res, 1997; 755:313-318.

Nader MA, Grant KA, Davies HML, Mach RH, Childers SR. The reinforcing and discriminative stimulus effects of the novel cocaine analog 2-ß-propanoyl-3ß-(4-tolyl)-tropane in rhesus monkeys. J Pharmacol Exp Ther 1997; 280: 541-550.

Porrino LJ, Miller M, -Rowe AH, Thornley C, Matasi JJ, Davies HML. Local Cerebral Metabolic Effects of the Novel Serotonin-Selective Tropane Analog, WF-31: Comparisons to Fluoxetine. Synapse, 1997; 27:26.

Selley DE, Nestler EJ, Breivogel CS and Childers SR. Opioid receptor-coupled G-proteins in rat locus coeruleus membranes: Decrease in G-protein activity after chronic morphine treatment. Brain Res, 1997; 746:10-18.

Sim LJ, Selley DE, and Childers SR. Autoradiographic visualization in brain of receptor-G-protein coupling using [35S]GTP?S binding. In: Methods in Molecular Biology, vol. 83: Receptor Signal Transduction Protocols (ed. R.A.J. Chaliss), Humana Press, Totowa, NJ, 1997; 117-132.

Sim LJ, Xiao R and Childers SR. In vitro autoradiography of 5-HT1A-stimulated [35S]GTP?S binding in rat brain. Brain Res. Bull, 1997;44:39-45. (add to WEB)

Sim LJ, Selley DE, and Childers SR. In vitro autoradiographic localization of receptor-stimulated [35S]GTP?S binding. In: Neuromethods, vol. 31: G-Protein Methods and Protocols (ed. R. Mishra, G.B. Baker and A.A. Boulton), Humana Press, Totowa, NJ, 1997; 1-27.

Sizemore, GM, Gaspard TM, Kim SA, Walker LE, Vrana SL, Dworkin SI. Dose-effect functions for cocaine self-administration: effects of schedule and dosing procedure. Pharmacol. Biochem. Behav: 57, 523-531, 1997.

Smith, JE (Ed.). Current issues in psychostimulant research, Special Issue Pharmacol Biochem Behav, vol 57 no.3, 1997.

Vrana SL, Vrana KE. Substance Abuse and Gene Expression. In: Drug Addiction and its Treatment: Nexus of Neuroscience and Behavior. Johnson B and Roache J (eds.), Lippincott-Raven Publishers, 1997; 317-338.

Yoburn BC, Selley DE, Breivogel CS, and Childers SR. Time-dependent effects of in vivo pertussis toxin on morphine analgesia and G-proteins in mice. Pharmacol Biochem Behav, 1997; 56:465-469.

1998

Bennett, B. A.; Hollingsworth, C. K.; Martin, R. S.; Childers, S. R.; Ehrenkaufer, R. E.; Porrino, L. J.; Davies, H. M. L. Prolonged Dopamine and Serotonin Transporter Inhibition After Exposure to Tropanes. Neuropharmacology 1998, 123-130.

Birmingham AM, Nader SH, Grant, KA, Davies HML, Nader MA. Further evaluation of the reinforcing effects of the novel cocaine analog 2-ß-propanoyl-3-ß-(4-tolyl)-tropane (PTT) in rhesus monkeys. Psychopharmacology 1998; 136: 139-147.

Daunais, J. B.: Hart, S. L.; Smith, H. H.; Letchworth, S. R.; Davies, H. M. L.; Sexton, T.; Bennet, B. A.; Childers, S. R.; Porrino, L. J. Long-Acting Blockade of Biogenic Amine Transporters in Rat Brain by Administration of the Potent Novel Tropane 2?-Propanoyl-3?-(2-naphthyl)-tropane. J. Pharmacol. Exp. Ther. 1998, 285, 1246-1254.

Davies, H. M. L.; Hodges, L. M.; Thornley, C. T. Rhodium(II)-Catalyzed Decomposition of Vinyldiazomethanes in the Presence of 1,2-Dihydropyridines: Synthesis of the 6-Azabicyclo[3.2.2]nonane Nucleus. Tetrahedron Lett. 1998, 39, 2707-2710.

Davies HML.; Cao G Cation Induced Rearrangement of Tropanes to 6-azabicyclo[3.2.1]octanes. Tetrahedron Lett. 1998, 39, 5943-5946.

Davies, HML. 3 + 4 Annulations Between Rhodium-Stabilized Vinylcarbenoids and Dienes., invited book chapter in Advances in Cycloaddition, Harmata, M. Ed.; JAI Press: 1998. Vol. 5. pp 119-164.

Davies, H. M. L. Rhodium-Stabilized Vinylcarbenoid Intermediates in Organic Synthesis. Curr. Org. Chem., invited review article, 1998, 2, 463-488.

De Montis, M.G., Co, C., Dworkin, S.I. and Smith, J.E. Modification of dopamine D1 receptor complex in rats self-administering cocaine. Europ. J. Pharmacol. 362:9-15, 1998.

Yan Z, Vrana SL, Vrana KE, Song W-J, and Surmeier DJ (1998) The application of RT-PCR techniques to the analysis of mRNA in tissue and single cells. In: Receptor Localization: Laboratory Methods and Procedures. Ariano MA (ed), John Wiley and Sons, pp. 160-181.

1999

Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Vogt LJ & Sim-Selley. Chronic ?9-Tetrahydrocannabinol Treatment Produces a Time-Dependent Loss of Cannabinoid Receptors and Cannabinoid Receptor-Activated G Proteins in Rat Brain. 1999, 73:2447-2459.

Davies, H. M. L. Dirhodium Tetra(N-arylsulfonylprolinates) as Chiral Catalysts for Asymmetric Transformations of Vinyl- and Aryldiazoacetates. Eur. J. Org. Chem. 1999, 2459-2469.

Davies, H. M. L.; Stafford, D. G.; Hansen, T. Catalytic Asymmetric Synthesis of Diarylacetates and 4,4-Diarylbutanoates. A Formal Asymmetric Synthesis of (+)-Sertraline. Org. Lett. 1999, 1, 233.

Davies, H. M. L.; Hansen, T.; Hopper, D. Highly Regio-, Diastero- and Enantioselective C-H Insertions of Methyl Aryldiazoacetates into Cyclic N-Boc Protected Amines. Asymmetric Synthesis of Novel C-2 Symmetric Amines and threo-Methyphenidate. J. Am. Chem. Soc., 1999, 121, 6509.

Freeman WM, Walker SJ, and Vrana KE (1999) Quantitative RT-PCR: Pitfalls and Potential BioTechniques 26:112-125.

Hemby, S.E., Co, C., Dworkin, S.I. and Smith, J.E. Synergistic elevations in nucleus accumbens extracellular dopamine concentrations during self-administration of cocaine/heroin combinations (speedball) in rats. J. Pharmacol. Exptl. Ther. 288:274-280, 1999.

Letchworth SR, Vaughan R, Sexton T, Childers SR Vrana KE, Porrino LJ. Chronic cocaine administration differentially regulates dopamine transporter mRNA and protein. J. Neurochem. 1999;75:1982-1989.

Nader MA, Green KL, Luedtke RR, Mach RH. The effects of benzamide analogues on cocaine self-administration in rhesus monkeys. Psychopharmacology, 1999; 147: 143-152.

Roberts, D.C.S., Phelan, R., Hodges L.M., Hodges M.M. Bennett, B., Childers, S and Davies, H.M.L. Self-administration of cocaine analogs. Psychopharmacology, 144 (1999) 4, 389-397.

Sinnott RS, Mach RH, Nader MA. Dopamine D2/D3 receptors modulate cocaine?s reinforcing and discriminative stimulus effects in rhesus monkeys. Drug Alcohol Dep 1999; 54: 97-110.

Sizemore, G.M., Cannon, D.G., Smith, J.E. and Dworkin, S.I. The effects of acutely administered cocaine on responding maintained by a progressive ratio schedule of food presentation. Submitted to J. Exptl. Anal. Behav., 1999.

Sizemore, G.M., Co, C. and Smith, J.E. Ventral pallidal extracellular-fluid levels of dopamine, serotonin, gamma amino butyric acid and glutamate during cocaine self-administration. Submitted to Psychopharmacol, 1999.

Stokes AH, Hastings TG, Zigmond MJ, Vrana KE. Cytotoxic and genotoxic potential of dopamine. J Neurosci Res 1999; 55:659-664.

Vrana, KE. How do the regulatory and catalytic domains get together. (News and View Nature Structural Biology 1999; 6:401-402.

2000

Brebner, K. and Roberts, DCS Intra-VTA baclofen attenuates cocaine self-administration on a progressive ratio schedule of reinforcement. Pharmacology, Biochemistry and Behavior 66 (2000) 857-862.

Davies, H. M. L. Asymmetric Synthesis Using Vinylcarbenoid Chemistry, in "Carbenes & Related Intermediates" (St. Petersburg Uni Press), invited review article, submitted

Freedland CS, Smith HR, Hart SL, Daunais JB, Davies HM, Porrino LJ. A comparison of the behavioral effects of the repeated administration of PTT,2β-propanoyl-3β-(4-tolyl)tropane and cocaine. Brain Res 2000; 869(1 2)98-104.

Freedland CS, Poston JS, Porrino LJ. Effects of SR141716A, a central cannabinoid receptor antagonist, on food-maintained responding. In revision.

Freeman WM, Roberston DJ, Vrana KE. Fundamentals of DNA hybridization arrays for gene expression analysis. BioTechniques 2000; 29:1042-1055.

Freeman WM, Yohrling GJ, Daunais JB, Gioia L, Hart SL, Porrino LJ, Davies HML, and Vrana KE. A novel -(4-tolyl)-tropane (PTT) reduces tyrosine$-propanoyl-3$cocaine analog, 2 hydroxylase in the mesolimbic dopamine pathway, Alcohol Drug Dependence 2000; 61:15-21.

Graham JH, Porrino LJ. Metabolic mapping of the substrates of cocaine self-administration in rats. Neuropsychopharmacology, submitted.

Jiang GC-T, Yohrling GJ IV, Schmitt JD, Vrana KE. Identification of substrate binding and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling. J Mol Biol 2000; 302:1005-1017. [cover article]

Letchworth SR, Smith JR, Porrino LJ, Bennett BA, Davies HM, Sexton T, Childers SR. Characterization of a tropane radioligand, [(3)H]2β-propanoyl-3β-(4-tolyl) tropane ([3)H]PTT), for dopamine transport sites in rat brain. J Pharmacol Exp Ther 2000; 293(2):686-696.

Lile J, Morgan D, Nader MA. First- vs. last-session substitution: An evaluation of the reinforcing effects of cocaine and the cocaine analog 2ß-propanoyl-3ß-(4-tolyl)-tropane (PTT) Exp Clin Psychopharmacol, in press.

Lile J, Morgan D, Nader MA. Single- vs. multiple-session substitution: an evaluation of the reinforcing effects of cocaine and the cocaine analog 2ß-propanoyl-3ß-(4-tolyl)-tropane (PTT). Exp Clin Psychopharmacol 2000; 8: 424-433.

Lile J, Morgan D, Freedland CS, Sinnott RS, Davies HML, Nader MA. Self-administration of two long-acting monoamine transport blockers in rhesus monkeys. Psychopharmacology 2000; 152: 414-421.

Mach RH, Nader MA, Ehrenkaufer RL, Gage HD, Childers SR, Hodges LM, Hodges MW, Davies HML. Fluorine- 18 Labeled Tropane Analogs for PET Imaging Studies of the Dopamine Transporter. Synapse, in press.

Martin TJ, Kim SA, Cannon DG, Sizemore GM, Bian D, Porecca F, Smith JE. Antagonism of delta2 opioid receptors by naltrindole-5'-isothiocyanate attenuates heroin self-administration but not antinociception in rats. Pharmacol Exp Ther 2000;294:975-982.

Martin TJ, Kim SA, Cannon DG, Sizemore GM, Bian D, Porreca F, Smith JE. Antagonism of delta2 opioid receptors by naltrindole-5'-isothiocynate attenuates heroin self-administration but not analgesia in rats. J Pharmacol Exp Ther; 2000; 294:975-982.

Moore R, Childers SR and Sim LJ. Agonist-stimulated [35S]GTP?S binding in brain: modulation by endogenous adenosine. Neuropharmacol., 2000; 39:282-289.

Morgan D, Grant KA, Prioleau OA, Nader SH, Kaplan JR, Nader MA. Predictors of social status in cynomolgus monkeys (macaca fascicularis) after group formation. Am J Primatol, 2000; 52: 115-131.

Morgan D, Nader MA. Acquisition of intravenous cocaine self-administration with concurrent access to food in cynomolgus monkeys. Exp Clin Psychopharmacol 2000; 8: 554-565.

Porrino LJ, Lyons D. Orbital and medial prefrontal cortex and psychostimulant abuse: studies in animal models. Cerebral Cortex 2000; 10:326-333.

Roberts, DCS, Brebner, K GABA Modulation of Cocaine Self-administration. Proceedings of the New York Academy of Science 909 (2000) 145-158.

Sim L, Selley DE, Vogt LJ, Childers SR, Martin TJ. Chronic heroin self-administration desensitizes mu opioid receptor-activated G-proteins in specific regions of rat brain. J Neurosci 2000;20:4555-4562.

Sim-Selley LJ, L.J. Vogt, R. Xiao, S.R. Childers and D.E. Selley, Region-specific alterations in 5-HT1A receptor-stimulated G-protein activity in rat brain following chronic buspirone administration, Eur. J. Pharmacol., in press.

Sizemore GM, Co C, Smith JE. Ventral pallidal extracellular-fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration. Psychopharmacol 2000; V. 150:391-398.

Sizemore, GM and TJ Martin. Toward a mathematical description of dose-effect functions for self-administered rugs. Psychopharmacol 2000;153:57-66.

Stokes AH, Lewis DY, Lash L, Jerome WG III, Grant KW, Aschner M, Vrana KE. Dopamine toxicity in neuroblastoma cells: Role of glutathione and apoptosis. Brain Res, 2000; 858:1-8.

Stokes AH, Xu Y, Daunais J, Tamir H, Gershon MD, Butkerait P, Kayser B, Altman J, Beck W, Vrana KE. p-Ethynylphenylalanine (pEPA): A potent inhibitor of tryptophan hydroxylase. J Neurochem, 2000; 74:2067-2073.

Yohrling IV GJ, Jiang GC-T, Mockus SM, Vrana KE. Intersubunit binding domains within tyrosine hydroxylase and tryptophan hydroxylase. J Neurosci Res 2000; 61:313-320.

2001

Blanchard-Fillion B, Souza JM, Friel T, Jiang GC-T, Vrana K, Sharov V, Barron L, Schoneich C, Quijano C, Alvarez B, Radi R, Przedborski S, Fernando GS, Horwitz J, Ischiropoulos H. Nitration and inactivation of tyrosine hydroxylase by peroxynitrite. J Biol Chem 2001, 276:46017-46023.

Bothwell S, Meredith GE, Phillips J, Staunton H, Doherty C, Grigorenko E, Glazier S, Deadwyler SA, O’Donovan CA, Farrell M (2001) Neuronal hypertrophy in the neocortex of patients with temporal lobe epilepsy. J Neurosci 21:4789-4800.

Brebner K, Childress AR, Roberts DCS (2002) A potential role for GABAB agonists in the treatment of psychostimulant addiction. Alcohol and Alcoholism, 37: 478-484.

Brennan K, Roberts DCS, Anisman H and Merali Z (2001) Individual differences in sucrose consumption in the rat: motivational and neurochemical correlates of hedonia. Psychopharmacology 157: 269-276

Daunais JB, Sim-Selley LS, Letchworth SR, Smith HR, Childers SR, Porrino LJ. Functional and anatomical localization of mu opioid receptors in the primate striatum and extended amygdala. J Comp Neurol 2001; 433:471 485.

Davies HML, Gilliatt V, Kuhn LA, Saikali E, Ren P, Hammond PS, Sexton T, Childers SR. Synthesis of 2-beta-acyl-3-beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transporter sites. J. Med. Chem 2001, 44, 1509-1515

Davies HML, Hodges LM, Gregg TM. Dasteroselective kinetic protonation of exocyclic enolates derived from bicyclic ketones: Control of stereochemistry mediated by bridging heteroatoms. J. Org. Chem. 2001, 66, 7898.

Davies HML, Ren P, Kong NX, Sexton T, Childers SR. Synthesis and monoamine transporter affinity of -(4-(2-pyrrolyl)phenyl)-8-azabicyclo[3.2.1}octanes andb3 -(6-indolyl)-8-azabicyclo[3.2.1}octanes. Biorg. Med. Chem. Lett., 2001, 11,b3 487.

Davies HML, Venkatataramani C. Kinetic resolution and double stereodifferentiation in catalytic asymmetric C-H activation of 2-substituted pyrrolidines. Org. Lett. 2001, 3, 1773-1775.

Deadwyler SA (2001) Behavioural significance of hippocampal plasticity. In: The Mutable Brain: Dynamic and Plastic Features of the Developing and Mature Brain (Kaas J, ed).

Freedland CS, Poston J, Porrino LJ. Effects of SR141716A, a novel cannabinoid receptor antagonist on food-maintained responding. Pharmacol Biochem Behav 2001; 67:265-270.

Freedland CS, Sharpe AL, Samson HH, Porrino LJ. Effects of SR141716A on ethanol and sucrose self-administration. Alcohol Clin Exp Res 2001; 25:277-282.

Freeman WM, Brebner K, Lynch WJ, Robertson DJ, Roberts DCS, Vrana KE (2001) Cocaine-responsive gene expression changes in rat hippocampus. Neuroscience 108: 371-380

Freeman WM, Brebner K, Lynch WJ, Robertson DJ, Roberts DCS, Vrana KE. Cocaine-responsive gene expression in rat hippocampus. Neuroscience 2001, 108:371-380.

Freeman WM, Nader MA, Nader SH, Robertson DJ, Gioia L. Mitchell SM, Daunais JB, Porrino LJ, Friedman DP, Vrana, KE. Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression. J Neurochem 2001; 77:542-549.

Letchworth SR, Nader MA, Smith HR, Friedman DP, Porrino LJ. Progression of changes in copamine transporter density as a result of cocaine self-administration in rhesus monkeys. J Neurosci 2001; 21:2799-2807.

Letchworth SR, Nader MA, Smith HR, Vinsant SL, Moore RJ, Friedman DP, Porrino LJ. Cocaine self-administration in rhesus monkeys: progression of changes in dopamine transporter binding site density. J Neurosci 2001; 21: 2799-2807.

Letchworth SR, Nader MA, Smith HR, Vinsant SL, Moore RJ, Friedman DP, Porrino LJ. Cocaine self-administration in rhesus monkeys: progression of changes in dopamine transporter binding site density. J Neurosci 2001; 21: 2799-2807.

Maher CE, Martin TJ, Eisenach JC and Childers SR. Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord. Brain Res 2001;895,1-8.

Nader MA, Morgan D. Effects of negative punishment contingencies on cocaine self-administration by rhesus monkeys. Behav Pharmacol 2001; 12: 91-99.

Nader MA, Morgan D. Effects of negative punishment contingencies on cocaine self-administration by rhesus monkeys. Behav Pharmacol 2001; 12: 91-99.

Sinnott RS, Nader MA. Modulation of cocaine’s discriminative stimulus effects by dopamine D1 agonists in rhesus monkeys. Pharmacol Biochem Behav 2001; 68: 301-309.

Sinnott RS, Nader MA. Modulation of cocaine’s discriminative stimulus effects by dopamine D1 agonists in rhesus monkeys. Pharmacol Biochem Behav 2001; 68: 301-309.

Walker SJ, Grant KA, Vrana KE. Comparison of the repeat polymorphism in the 5' flanking region of the CYP2E1 gene in humans and non-human primates. Alcoholism: Clin and Exp Res 2001; 25:1114-1118.

2002

Brebner K, Childress AR, Roberts DCS (2002) A potential role for GABAB agonists in the treatment of psychostimulant addiction. Alcohol and Alcoholism, 37: 478-484.

Brebner K, Froestl, W, Roberts DCS (2002) The GABAB antagonists CGP56433A attenuates the effect of baclofen on cocaine, but not heroin self-administration. Psychopharmacology 160: 49-55

Cibelli JB, Grant KA, Chapman KB, Cunniff K, Worst T, Green HL, Walker SJ, Gutin PH, Vilner L, Tabar V, Dominko T, Kane J, Wettstein PJ, Studer L, Vrana KE, West MD. Parthenogenetic development in non-human primates. Science 2002, 295:819.

Cousins MS, Roberts, DCS and de Wit H (2002) GABAB receptor agonists for the treatment of drug addiction: a review of recent findings. Drug and Alcohol Dependence 65: 209-220

Davies HML, Abbas W, Townsend RB. Catalytic asymmetric C–H activation by methyl thiophen-3-yldiazoacetate applied to the synthesis of (+)-cetiedil. Tetrahedron Lett. 2002, 43, 4981.

Davies HML, Gregg TM. Asymmetric synthesis of (+)-indatraline using rhodium catalyzed C–H activation. Tetrahedron Lett. 2002, 43, 4951.

Davies HML, Hodges L.M. Rhodium carboxylate catalyzed decomposition of vinyldiazoacetates in the presence of heterodienes: Asymmetric synthesis of the 6-azabicylo[3.2.2]octane and 6-azabicyclo[3.2.2]nonanone ring systems. J. Org. Chem. 2002, 67, 5683.

Davies HML, Jin Q, Ren P. Catalytic asymmetric benzylic C-H activation by means of carbenoid induced C–H insertions. J. Org. Chem. 2002, 67, 4165.

Davies HML, Ren P, -aryltropanes withbKong NX, Sexton T, Childers SR. Synthesis of iodinated 3 selective binding to either the dopamine or serotonin transporters. Biorg. Med. Chem. Lett., 2002, 12, 845.

Davies HML, Venkataramani C. Catalytic asymmetric synthesis of beta-amino acids. Angew. Chem. 2002 41, 2197.

Deadwyler SA (2001) Behavioural significance of hippocampal plasticity. In: The Mutable Brain: Dynamic and Plastic Features of the Developing and Mature Brain (Kaas J, ed).

Freeman WM, Brebner K, Lynch WJ Robertson DJ, Roberts DCS, Vrana KE (2002) Changes in rat frontal cortex gene expression following chronic cocaine. Mol. Brain Res. 104: 11-20

Freeman WM, Brebner K, Patel KM, Lynch WJ, Robertson DJ, Roberts DCS, Vrana KE. Changes in rat frontal cortex gene expression following chronic cocaine. Mol Brain Res 2002; 104:11-20.

Freeman WM, Dougherty K, Sally E. Vacca, Vrana KE. An interactive database of cocaine-responsive neuronal gene expression. Scientific World Journal 2002, 2:701-706.

Hampson RE, Simeral JD, Deadwyler SA (2002) "Keeping on Track:" Firing of Hippocampal Neurons During Delayed-Nonmatch-to-Sample Performance. J Neurosci RC 198.

Haycock JW, Kumer SC, Lewis DA, Vrana KE, Stockmeier CA. A monoclonal antibody to tryptophan hydroxylase: Applications and identification of the epitope. J Neurosci Meth, 2002, 114:205-211.

Kelly M, Deadwyler SA (2002) Acquisition of a novel behavior induces higher levels of Arc mRNA than does overtrained performance. Neurosci 110:617-627.

Lile J, Morgan D, Grant KA, Gage HD, Mach RH, Kaplan JR, Prioleau O, Nader SH, Buchheimer N, Ehrenkaufer RL, Nader MA. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nature Neuroscience 2002; 5: 169-174.

Lile JA, Morgan D, Birmingham AM, Wang Z, Woolverton WL, Davies HM, Nader MA. The reinforcing efficacy of the dopamine reuptake inhibitor PTT as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeys. J Pharmacol Exp Ther 2002; 303: 640-648.

Morgan D, Grant KA, Gage HD, Mach RH, Kaplan JR, Prioleau O, Nader SH, Buchheimer N, Ehrenkaufer RL, Nader MA. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nature Neuroscience 2002; 5: 169-174.

Nader MA, Daunais JB, Moore T, Nader SH, Moore RJ, Smith HR, Friedman DP, Porrino LJ. Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology 2002; 27: 35-46.

Nader MA, Daunais JB, Moore T, Nader SH, Moore RJ, Smith HR, Friedman DP, Porrino LJ. Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology 2002; 27: 35-46.

Nader MA, Sinnott RS, Mach RH, Morgan D. Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist. Psychopharmacology 2002; 163: 292-301.

Nagashima T; Davies HML. Catalytic asymmetric cyclopropanation using bridged dirhodium tetraprolinates on solid support, Org. Lett. 2002; 4, 1989.

Nishiyama H, Konno M, 3-allyl complexes by reaction ofhAoki K, Davies HML. Facile formation of chloro- vinyldiazoacetates and ruthenium(II) arene complexes,. Organometallics 2002, 21, 2536.

Roberts DCS, Brebner K, Vincler M, Lynch WJ (2002) Patterns of cocaine self-administration in rats produced by various access conditions under a discrete trials procedure. Drug and Alcohol Dependence, 67: 291-299

Stokes AH, Freeman WM, Mitchell SG, Burnette TA, Hellman GE, Vrana KE. Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity. NeuroToxicology 2002; 162:1-11.

Weber S, Dorman DC, Lash LH, Erikson K, Vrana, KE, Aschner M. Effects of manganese on the developing rat brain: oxidative-stress related endpoints. NeuroToxicology 2002; 23:169-175.

Yohrling IV GJ, Jiang GC-T, DeJohn MM, Robertson DJ, Vrana KE, Cha J-HJ. Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington’s disease. J Neurochem 2002, 82:1416-1423.

2003

Lile JA, Nader MA. The abuse liability and therapeutic potential of drugs evaluated for cocaine addiction as predicted by animal models. Curr Neuropharmacol, 1: 21-46.

Macey D, Smith HR, Nader MA, Porrino LJ. Chronic cocaine self-administration upregulates the norepinephrine transporter in the bed nucleus of the stria terminalis of the rhesus monkey. J Neurosci, 2003; 23: 12-16.

Smith JE, Koves TR & Co C. Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration. Neuroscience, 2003;117:461-475.

In Press & Sumitted

Freeman WM, Brebner K, Patel KM, Lynch WJ, Roberts DCS, Vrana KE. Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression. J Neurochem Res 2002, in press.

Lile JA, Wang Z, Woolverton WL, France JE, Gregg TC, Davies HML, Nader MA. The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics. Submitted to J Pharmacol Exp Ther.

Lile JA, Morgan D, Birmingham AM, Wang Z, Woolverton WL, Davies HM, Nader MA. The reinforcing efficacy of the dopamine reuptake inhibitor PTT as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeys. J Pharmacol Exp Ther, in press.

Lyons D, Whitlow CT, Smith HR, Porrino LJ. Brain imaging: functional consequences of ethanol in the central nervous system. In: Galanter M, Lieber C, Gottheil E, Fuller R, Paredes A, eds, Recent Developments in Alcoholism, Vol XVI: The Consequences of Alcoholism. New York, Plenum Press; in press.

Martin TJ, Kim SA, Lyupina Y, Smith JE. Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: Evidence from focal injections of β-funaltrexamine. J Pharmacol Exp Ther 2000; In Press.

Nader MA, Daunais JB, Moore M. Nader S, Moore R, Smith HR, Friedman DP, Porrino LJ. Effects of long-term cocaine self-administration on mesolimbic and nigrostriatal dopamine systems in rhesus monkeys. Neuropsychopharmacology; in press.

Nader MA, Sinnott RS, Mach RH. Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist. Psychopharmacology, in press.

Porrino LJ, Lyons D, Miller MD, Smith HR, Daunais JB, Friedman DP, Nader MA. Metabolic mapping of the effects of cocaine self-administration in the nonhuman primate. J Neurosci, in press.