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 Pulmonary & Critical Care |
 Diseases and Conditions |
| Procedures and Treatments |
| Clinics/Patient Information |
| Locate A Physician |
| Referrals |
| Research |
| Education |
 Faculty |
 Norman Adair, MD |
| Eugene R. Bleecker, MD |
| Arjun Bijoy (Raja) Chatterjee, M |
| Robert Chin, MD |
| John Conforti, DO |
| Annette Hastie, PhD |
| Gregory Hawkins, PhD |
| Duncan Hite, MD |
| Wendy Moore, MD |
| Peter Morris, MD |
| Josyf Mychaleckyj, MA, DPhil |
| Jill Ohar, MD |
| Rodolfo Pascual, MD |
| Mary Fontana-Penn, MD |
| Raymond Penn, PhD |
| Stephen P. Peters, MD, PhD |
| Michael Seeds, PhD |
| Siqun (Lilly) Zheng, MD |
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| Staff |
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Annette Hastie, PhD  My bachelor’s degree was obtained at Oberlin College and my doctorate at the University of Pittsburgh. I received postdoctoral training at Johns Hopkins University School of Hygiene in Baltimore, MD where I met my husband, Robin Hastie MD, BChir, PhD at Temple University School of Medicine in Philadelphia, PA. My first faculty appointment in 1984 was in the Pulmonary Division of the Department of Medicine at Jefferson Medical College in Philadelphia, PA., where I remained until recruited as an associate Professor to join Wake Forest University School of Medicine, in the Department of Internal Medicine, Section on Pulmonary/Critical Care Medicine in 2003.
My principal research interests over the last 20 years have focused on airway epithelial cell function in normal healthy individuals and patients with either asthma or allergic rhinitis. NIH funded studies examine airway epithelial stimulation of fibroblast and myofibroblast production of extracellular matrix, primarily collagen types I and III, in an in vivo model of antigen-induced inflammation. Specific inflammatory mediators from epithelial cells which induce fibrogenesis in asthmatic airways are being identified. Additional studies investigate changes in cytoskeletal organization, primarily proteins such as VASP, and the heat shock protein, HSP 27, which are involved in actin dynamics, cell-cell, and cell-matrix interaction of airway epithelial cells, and of fibroblasts/myofibroblasts. Cytoskeletal reorganization and consequent signaling is hypothesized to be crucial for repair and replacement processes following antigen-induced inflammatory injury. Modulation of these responses by -agonist and steroid therapy is also under study. Differences in gene expression for targeted and potentially associated proteins involved in these processes are being examined. Finally, gene expression of the structural proteins of cilia in airway epithelial cells, and modulation of these genes during differentiation are under investigation. Extramural interest include gardening and growing orchids, fine art (painting, architecture, and sculpture) and contemporary crafts (glass, wood, metalwork and ceramics,), books and music |
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