Education:

• Undergraduate: University of North Carolina at Greensboro, Department of Nutrition, BS, 2000
• Postgraduate: University of North Carolina at Greensboro, Department of Nutrition, PhD, 2004
• Fellowship: Wake Forest University School of Medicine, Department of Pathology, 2004-present

Research Interests:

Atherosclerosis, Obesity, Insulin Resistance, Fatty Acids, Hepatic Lipid Metabolism and Gene Regulation, Plasma Lipoprotein Metabolism, Hormonal Regulation of Lipid Metabolism

Recent Publications:

Temel RE, Brown JM, Ma Y, Tang W, Rudel LL, Ioannou YA, Davies JP, Yu L. Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1-dependent. J Lipid Res. 2009 Jan 13. [Epub ahead of print]

Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong MN, Wibley AL, Shah R, Davis MA, Kelley K, Wilson MD, Kent C, Parks JS, Rudel LL. Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis. Circulation. 2008 Sep 30;118(14):1467-75.

Zhu X, Lee JY, Timmins JM, Brown JM, Boudyguina E, Mulya A, Gebre AK, Willingham MC, Hiltbold EM, Mishra N, Maeda N, Parks JS. Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem. 2008 Aug 22;283(34):22930-41.

Brown JM, Bell TA 3rd, Alger HM, Sawyer JK, Smith TL, Kelley K, Shah R, Wilson MD, Davis MA, Lee RG, Graham MJ, Crooke RM, Rudel LL. Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss. J Biol Chem. 2008 Apr 18;283(16):10522-34.

Brown JM, Shelness GS, Rudel LL. Monounsaturated fatty acids and atherosclerosis: opposing views from epidemiology and experimental animal models. Curr Atheroscler Rep. 2007 Dec;9(6):494-500.

Brown JM, Chung S, Das A, Shelness GS, Rudel LL, Yu L. CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cells. J Lipid Res. 2007 Oct;48(10):2295-305.

Brown JM, Rudel LL, Yu L. NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells. Biochem J. 2007 Sep 1;406(2):273-83.

Bell TA 3rd, Brown JM, Graham MJ, Lemonidis KM, Crooke RM, Rudel LL. Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1814-20.

Yu L, Bharadwaj S, Brown JM, Ma Y, Du W, Davis MA, Michaely P, Liu P,
Willingham MC, Rudel LL. Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake. J Biol Chem. 2006 Mar 10;281(10):6616-24.

Brown JM, Chung S, McIntosh M.  (2006) Lipid-lowering actions of trans-10, cis-12 CLA in primary cultures of human (pre)adipocytes. In "Advances in Conjugated Linoleic Acid Research, Vol. 3" (P. Yurawecz & M. Pariza, eds.) pp. 233-244, Chapter 13. AOCS, Champaign, IL

Chung S, Brown JM, Provo JN, Hopkins R, McIntosh MK. Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. J Biol Chem. 2005 Nov 18;280(46):38445-56.

Chung S, Brown JM, Sandberg MB, McIntosh M. Trans-10,cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling. J Lipid Res. 2005 May;46(5):885-95.

Brown JM, Boysen MS, Chung S, Fabiyi O, Morrison RF, Mandrup S, McIntosh MK.  Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J Biol Chem. 2004 Jun 18;279(25):26735-47.

Brown JM, McIntosh MK. Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity. J Nutr. 2003 Oct;133(10):3041-6. Review.

Brown JM, Boysen MS, Jensen SS, Morrison RF, Storkson J, Lea-Currie R, Pariza M, Mandrup S, McIntosh MK. Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. J Lipid Res. 2003 Jul;44(7):1287-300.

Evans M, Brown J, McIntosh M. Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J Nutr Biochem. 2002 Sep;13(9):508.

Brown JM, Halvorsen YD, Lea-Currie YR, Geigerman C, McIntosh M. Trans-10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells from human adipose tissue. J Nutr. 2001 Sep;131(9):2316-21.

Brown M, Evans M, McIntosh M.  Linoleic acid partially restores   the triglyceride content of conjugated linoleic acid-treated cultures of 3T3-L1  preadipocytes. J Nutr Biochem. 2001 12(7); 381-387.

Awards and Honors:

• 2000 Undergraduate Research Poster Competition, 1st prize, University of North Carolina-Greensboro, Greensboro, NC
• 2000 NC Academy of Science Annual Research Symposium, 2nd place (Derieux Award) Biochemistry and Physiology Competition
• 2000-2001 Recipient of the Jefferson-Pilot Fellowship
• 2000-2001 Recipient of the HES Alumni Association Scholarship, University  of North Carolina-Greensboro, Greensboro, NC
• 2001-2002 President: Nutrition Graduate Student Association (NGSA), University of North Carolina-Greensboro, NC
• 2001-2002 Most outstanding graduate student: Dept. of Nutrition, University of North of North Carolina-Greensboro, NC
• 2001-2002 Recipient of the North Carolina Institute of Nutrition Fellowship, University of North Carolina-Greensboro, NC
• 2001-2002 Recipient of the Mildred B. Davis Scholarship in Nutrition, University of North Carolina-Greensboro, NC
• 2002 Recipient of the American Society for Nutritional Science (ASNS) predoctoral fellowship (one fellowship awarded nationally)
• 2002 Recipient of the Robert R. Bryden Graduate Research Grant from the North Carolina Academy of Science
• 2003 Recipient of the Society for Experimental Biology and Medicine (SEBM) Young Investigator Travel Fellowship Grant (2002)
• 2002 Recipient of the School of Human Environmental Sciences (HES) graduate student travel grant, University of North Carolina-Greensboro
• 2002-2003 Recipient of the American Dietetic Association (ADA) Loyal E. Horton Memorial Scholarship
• 2003 Student member, UNCG, Department of Nutrition Chair Search Committee (2002-2003)
• 2002-2003 Recipient of the Naomi G. Albanese Doctoral Fellowship, University of North Carolina-Greensboro, Greensboro, NC
• 2003 One of twelve nationwide winners of the ASNS Procter & Gamble Graduate Student Research Awards Abstract Competition at the FASEB Conference in San Diego, CA.
• 2004 Recipient of the NIH travel fellowship to attend Keystone Symposia (B5) PPARs:Transcriptional Regulation of Metabolism and Metabolic Disease
• 2003 Invited reviewer for the SEBM Young Investigator Travel Fellowship Grant Abstract Competition for FASEB conference, San Diego, CA
• 2003-2004 Recipient of the Rev. and Mrs. G.D. Albanese Fellowship, University of North Carolina-Greensboro, Greensboro, NC
• 2004 Winner of the ASNS dietary bioactive food components research interest section poster competition at the FASEB conference, Washington, D.C.
• 2004 Winner of the ASNS Energy and Macronutrient Metabolism research interest section abstract competition at the FASEB conference, Washington, D.C.
• 2004 Winner of the ASNS nutrient-gene interactions research interest section poster competition at the FASEB conference, Washington, D.C.
• 2004 One of twelve nationwide winners of the ASNS Procter & Gamble Graduate Student Research Awards Abstract Competition at the FASEB Conference, Washington, D.C. (winner of the oral competition). 
• 2006-2008 Recipient of the Young Investigator Travel Award to attend the Kern Aspen Lipid Conference
• 2007 Recipient of the Peter J. Reeds Memorial Young Investigator Award; this award is given by the American Society for Nutrition for outstanding research in macronutrient metabolism accomplished within 5 years of receiving a Ph.D.
• 2007 Winner of the poster competition at the 2007 FASEB Summer Conference entitled "Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids"
• 2008 Winner of the poster competition at the 2008 Gordon Conference on Lipoprotein Metabolism. Waterville Valley Resort, NH