Recent Publications (selected):
Norris JM, Langefeld CD, Scherzinger AL, Rich SS, Bookman E, Beck SR, Saad MF, Haffner SM, Bergman RN, Bowden DW, Wagenknecht LE. Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family Study. Int J Obes Relat Metab Disord. 29:66-77 (2005)
Rich SS, Bowden DW, Haffner SM, Norris JM, Saad MF, Mitchell BD, Rotter JI, Langefeld CD, Wagenknecht LE, Bergman RN. A genome scan for fasting insulin and fasting glucose identifies a QTL on chromosome 17p: the IRAS Family Study. Diabetes 54:290-295 (2005)
Wheeler GL, Shi R, Beck SR, Langefeld CD, Lenchik L, Wagenknecht LE, Freedman BI, Rich SS, Bowden DW, Chen MY, Carr JJ. Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic families. Invest Radiol 40:97-10 (2005)
Lange LA, Norris JM, Langefeld CD, Nicklas BJ, Wagenknecht LE, Saad MF, Bowden DW. Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family study. Int J Obes Relat Metab Disord 29: 449-457 (2005)
Freedman BI, Bowden DW, Rich SS, Valis CJ, Sale MM, Williams AH, Brown WM, Beck SR, Anderson PJ, Langefeld CD. A genome scan for all-cause End-Stage Renal Disease in African Americans. Nephrol Dial Transplant 20:712-718 (2005)
Hiratani H, Bowden DW, Ikegami S, Shirasawa S, Shimizu A, Iwatani Y, Akamizu T. Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J Clin Endocrinol Metab. 90: 2898-903 (2005)
Liu Y, Burdon KP, Langefeld CD, Beck SR, Wagenknecht LE, Rich SS, Bowden DW, Freedman BI. T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the Diabetes Heart Study. J Am Soc Nephrol. 16:1085-90 (2005)
Bagwell AM, Bento JL, Mychaleckyj JC, Freedman2 BI, Langefeld CD, Bowden DW. Genetic analysis of HNF4A polymorphisms in Caucasian American type 2 diabetes. Diabetes 54:1185-1190 (2005)
Hsu FC, Lenchik L, Nicklas BJ, Lohman K, Register TC, Mychaleckyj J, Langefeld CD, Freedman BI, Bowden DW, Carr JJ. Heritability of Body Composition Measured by DXA in the Diabetes Heart Study. Obes Res. 13:312-319 (2005)
Sutton BS, Weinert S, Langefeld CD, Campbell J, Williams AH, Saad MF, Norris JM, Haffner SM, Bowden DW. Genetic analysis of adiponectin and obesity in Hispanic families: The IRAS Family Study. Hum Genet 117:107-118 (2005)
Freedman BI, Langefeld CD, Lohman K, Bowden DW, Carr JJ, Rich SS, Wagenknecht LE. The relationship between albuminuria and subclinical coronary and carotid artery disease. J Am Soc Nephrol. 16: 2156-2161 (2005)
Matsuzu K, Segade F, Wong MG, Clark OH, Perrier ND, Bowden DW. Glucose transporters in the thyroid. Thyroid 15: 549-554 (2005)
Engeler-Dusel JA, Burdon KP, Hicks PJ, Hawkins GA, Bowden DW, Freedman BI. Identification of podocin (NPHS2) gene mutations in African Americans with non-diabetic end-stage renal disease. Kidney Int 68:256-262 (2005)
Liu Y, Burdon KP, Langefeld CD, Beck SR, Wagenknecht LE, Rich SS, Bowden DW, Freedman BI. P-selectin gene haplotype associations with albuminuria in the Diabetes Heart Study. Kidney Int 68:741-746 (2005)
Segade F, Allred DC, Bowden DW. Functional characterization of the promoter of the human glucose transporter 10 gene..Biochim Biophys Acta. 1730:147-58 (2005)
Sale MM, Freedman BI, Hicks PJ, Williams AH, Langefeld CD, Gallagher CJ, Bowden DW, Rich SS. Loci contributing to height and body mass index in African American families ascertained for diabetes. Ann Hum Genet 69: 517-527 (2005)
Freedman BI, Hsu F-C, Langefeld CD, Rich SS, Herrington DM, Carr JJ, Xu J, Bowden DW, Wagenknecht LE. The impact of ethnicity and gender on subclinical cardiovascular disease: the Diabetes Heart Study. Diabetologia 48:2511-8 (2005)
Nicklas BJ, Mychaleckyj J, Kritchevsky S, Palla S, Lange LA, Lange EM, Messier SP, Bowden D, Pahor M. Physical Function and Its Response to Exercise: Associations With Cytokine Gene Variation in Older Adults With Knee Osteoarthritis. J Gerontol A Biol Sci Med Sci. 60(10):1292-1298 (2005)
Bowden DW, Lange LA, Langefeld CD, Brosnihan KB, Freedman BI, Carr JJ, Wagenknecht LE, Herrington DM. The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study. Am Heart J. 150(5):1032-1038 (2005)
Bento JL, Mychaleckyj JC, Hirakawa S, Rich SS, Freedman BI, Segade F. Genetic analysis of the GLUT10 glucose transporter (SLCC2A10) polymorphisms in Caucasian American type 2 diabetes. BMC Medical Genetics 6: 42 (2005)
Burdon KP, Langefeld CD, Beck SR, Wagenknecht LE, Carr JJ, Freedman BI, Bowden DW. Association of genes involved in lipid metabolism with measures of subclinical cardiovascular disease in the Diabetes Heart Study. J Med Genet 42(9):720-724 (2005)
Hsu F-C, Lange L, Saad M, Bowden D, Herrington D, Arnett D.Heritability of pulse pressure in three family studies (IRAS FamilyStudy, Diabetes Heart Study, Family Heart Study). Human Heredity 60:63-72 (2005)
Sutton BS, Langefeld CD, Williams AH, Norris JM, Saad MF, Haffner SM, Bowden DW. Association of proopiomelanocortin gene polymorphisms with obesity in the IRAS Family Study. Obesity Research 13:1491-8 (2005)
Gallagher CJ, Gordon CJ, Langefeld CD, Mychaleckyj JC, Freedman BI, Rich SS, Bowden DW, Sale MM .Association of the μ-opioid receptor gene with type 2 diabetes mellitus in an African American population. Mol Gene Metab 87:54-60 (2006)
Burdon KP, Langefeld CD, Wagenknecht LE, Carr JJ, Freedman BI, Herrington D Bowden DW. Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with type 2 diabetes mellitus: The Diabetes Heart Study. Diabetic Medicine 23:228-34 (2006)
Burdon KP, Bento JE, Langefeld CD, Palmer ND, Campbell JR, Beck SR, Carr JJ, Herrington D Freedman BI, Rich SS, Bowden DW Association of PTPN1 with coronary artery calcium in the Diabetes Heart Study. Diabetes 55:651-658 (2006)
Burdon KP, Langefeld CD, Beck SR, Wagenknecht LE, Carr JJ, Freedman BI, Herrington D Bowden DW. Variants of CD40 but not CD40L genes are associated with coronary artery calcification in the Diabetes Heart Study. Am Heart J.151:706-711 (2006)
Sutton BS, Langefeld CD, Campbell JK, Haffner SM, Norris JM, Scherzinger AL, Wagenknecht LE, Bowden DW. Genetic mapping of a 17q chromosomal region linked to obesity phenotypes in the IRAS Family Study. Int J Obesity 30:1433-1441 (2006)
Palmer ND, Langefeld CD, Campbell JK, Williams AH, Saad MF, Norris JM, Haffner SM, Rotter JI, Wagenknecht LE, Bergman RN, Rich SS, Bowden DW. Genetic mapping of disposition index and acute insulin response loci on chromosome 11q: the IRAS Family Study, Diabetes 55:911-918 (2006)
Register TC, Lenchik L, Hsu F-C, Lohman KK, Freedman BI, Bowden DW, Carr JJ. Type 2 diabetes is not independently associated with spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study. Bone 39(3):628-33 (2006)
Guo X, Saad MF, Langefeld CD, Williams AH, Cui J, Taylor KD, Norris JM, Jinagouda S, Darwin CH, Mitchell BD, Bergman RN, Sutton B, Chen Y-D, Wagenknecht LE, Bowden DW, Rotter JI. Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: The IRAS Family Study. Diabetes 55 1723-1730 (2006)
Freedman BI, Bowden DW, Sale MM, Langefeld CD, Rich SS. Genetic susceptibility contributes to renal and cardiovascular complications of type 2 diabetes mellitus. Hypertension 48:8-13 (2006)
Bowden DW, Rudock M, Ziegler J, Lehtinen AB, Xu J, Wagenknecht LE, Herrington D, Rich SS, Freedman BI, Carr JJ, Langefeld CD. Coincident linkage of Type 2 Diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the Diabetes Heart Study. Diabetes 55 1985-1994 (2006)
Bowden DW, Lohman K, Hsu F-C, Langefeld CD, Carr JJ, Wagenknecht LE, Freedman BI, Herrington DM. Hormone replacement therapy increases C-reactive protein in type 2 diabetes affected women in the Diabetes Heart Study. Diabetic Medicine 23:763-767 (2006)
Segade F, Daly KA, Allred D, Hicks PJ, Cox M, Brown WM, Hardisty-Hughes RE, Brown SDM, Rich SS, Bowden DW. Association of the FBXO11 gene with COME/ROM in the Minnesota COME/ROM Family Study. Arch Otolaryngol Head Neck Surg 132: 729-733 (2006)
Liu Y, Herrington D, Burdon KP, Langefeld CD, Rich SS, Bowden DW, Freedman BI, Wagenknecht LE. Functional polymorphism in the lymphotoxin alpha gene and carotid artery wall thickness: The Diabetes Heart Study. Eur J Cardiovasc Prev Rehabil. 13:655-657 (2006)
Elbein SC, Wang X, Karim MA, Freedman BI, Bowden DW, Shuldiner AR, Brancati FL, Kao WH. Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes. Diabetes 55:2909-2914 (2006)
Lange L, Burdon KP, Langefeld CD, Liu Y, Beck SS, Rich SS, Freedman BI, Brosnihan KB, Herrington D, Wagenknecht LE, Bowden DW. Heritability and expression of C-reactive protein in type 2 diabetes. Ann Hum Genet 70:717-725 (2006)
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