Recent Publications by PET Center Personnel
Fahey FH. Positron emission tomography instrumentation. Radiologic Clinics of North America 2001; 39:919-929. Data acquisition in PET imaging. J Nucl Med Technol 2002; 30:39-49.
Voytko ML, Mach RH, Gage HD, Ehrenkaufer RLE, Efange SMN, Tobin JR. Cholinergic activity of aged rhesus monkeys revealed by PET. Synapse 2001; 39:95-100.
Mach RH, Wheeler KT, Blair S, Yang B, Day CS, Blair JB, Choi SR, Kung HF. Preparation of a technetium-99m SPECT agent for imaging the sigma-2 receptor status of solid tumors. Journal of Labelled Compounds and Radiopharmaceuticals 2001; 44:899-908.
Fahey FH, Grow KL, Webber RL, Harkness BA, Bayram E, Hemler PF. ETACT: a novel approach to scintimammography. J Nucl Med 2001; 42:1121-1127.
Prielipp RC, Wall MH, Groban L, Tobin JR, Fahey FH, Harkness BA, Stump DA, James RL, Cannon MA, Bennett J, Butterworth J. Reduced regional and global cerebral blood flow during fenaldopam-induced hypotension in volunteers. Anesth Analg 2001; 93:45-52.
Mach RH, Huang Y, Buchheimer N, Kuhner R, Wu L, Morton TE, Wang L-M, Ehrenkaufer RL, Wallen CA, Wheeler KT. [18F]N-4’-fluorobenzyl-4-(3-bromophenyl)acetamide for imaging the sigma receptor status of tumors: comparison with [18F]FDG and [125I]IUDR. Nucl Med Biol 2001; 28:451-458.
Choi S-R, Yang B, Plossl K, Chumpradit S, Wey S-P, Acton PD, Wheeler KT, Mach RH, Kung HF. Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent. Nucl Med Biol 2001; 28:657-666.
Huang Y, Luedtke RR, Freeman RA, Wu L, Mach RH. Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands. J Med Chem 2001; 44:1815-1826.
Gage HD, Gage JC, Tobin JR, Chiari A, Xu Z-M, Mach RH, Efange SMN, Ehrenkaufer RLE, Eisenach JC. Morphine-induced spinal cholinergic activation: in vivo imaging with PET. Pain 2001; 91:139-145.
Gage HD, Voytko ML, Ehrenkaufer RLE, Tobin JR, Efange SMN, Mach RH. Reproducibility of repeated measures of cholinergic terminal density using [18F](+)-4-fluorobenzyltrozamicol and PET in the rhesus monkey brain. J Nucl Med 2000; 41:2069-2076.
Kalia VK, Al-Nabulsi I, Wallen CA, Zhang H, Wheeler KT. Radiation-induced DNA damage in tumors and normal tissues. VI. Estimation of the hypoxic fraction of experimental tumors. Radiat Res 2000; 152(5):548-556.
Wheeler KT, Wang L-M, Wallen CA, Childers SR, Cline JM, Keng PC, Mach RH. Sigma-2 receptors as a biomarker of proliferation in solid tumors. Br J Cancer 2000; 86:1223-1232.
Garrett AS, Flowers DL, Absher JR, Fahey FH, Gage HD, Keyes JW, Porrino LJ, Wood FB. Cortical activity related to accuracy of letter recognition. Neuroimage 2000; 11:111-123.
Luedtke RR, Freeman RA, Boundy V, Martin MW, Huang Y, Mach RH. Characterization of 125I-IABN, a novel benzamide selective for D2-like dopamine receptors. Synapse 2000; 38:438-449.
Mach RH, Nader MA, Ehrenkaufer RL, Gage HD, Childers SR, Hodges LM, Hodges MM, Davies HML. Fluorine-18 labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse 2000; 37:109-117.
McCain TW, Dunagan DP, Chin R, Oaks T, Harkness BA, Haponik EF. The usefulness of positron emission tomography in evaluating patients for pulmonary malignancies. Chest 2000; 118:1610-1615.
Sinnot RS, Mach RH, Nader MA. Dopamine D2/D3 receptors modulate cocaine’s reinforcing and discriminative stimulus effects in rhesus monkeys. Drug and Alcohol Dependence 1999; 54:979-110.
Efange SMN, Mach RH, Ehrenkaufer RLE, Nader MA, Khare AB, Smith CR, Morton TE. (+)-p-([18F]fluorobenzyl)spirotrozamicol { (+)-[18F]spiro-FBT}: synthesis and biological evaluation of a high-affinity ligand for the vesicular acetylcholine transporter (VAChT). Nucl Med Biol 1999; 26:189-192.
Efange SMN, Khare AB, Mach RH, Parsons SM. Hydroxylated decahydroquinolines as ligands for the vesamicol acetylcholine transporter: synthesis and biological evaluation. J Med Chem 1999; 42: 2862-2869.
Khare AB, Langason RB, Parsons SM, Mach RH, Efange SMN. N-(3-Iodophenyl)trozamicol (IPHT) and related inhibitors of vesicular acetylcholine transport: synthesis and preliminary biological characterization. Nucl Med Biol 1999; 26:609-617.
Nader MA, Green KL, Luedtke RR, Mach RH. The effects of benzamide analogues on cocaine self-administration in rhesus monkeys. Psychopharmacology 1999; 147:143-152.
Al-Nabulsi I, Wheeler KT. Radiation-induced DNA damage in tumors and normal tissues: V. Influence of pH and nutrient depletion on the formation of DNA-protein crosslinks in irradiated partially and fully hypoxic tumor cells. Radiat Res 1999; 151:188-194.
Kalandarishvili F, Wheeler KT. Accumulation of DNA damage pre- and posthepatectomized liver of aged rats. Mech Ageing Dev 1999; 110:25-35.
Nader MA, Grant KA, Gage HD, Ehrenkaufer RLE, Kaplan JR, Mach RH. PET imaging of dopamine D2 receptors with [18F]fluoroclebopride in monkeys: effects of isoflurane- and ketamine-induced anesthesia. Neuropsychopharmacology 1999; 21:589-596.
Mach RH, Wu L, West T, Whirrett BR, Childers SR. The analgesic tropane analogue (±)-SM-21 has a high affinity for s 2 receptors. Life Sciences 1999; 64:PL131-137.
Al-Nabulsi I, Mach RH, Sten K, Childers SR, Wheeler KT. Effect of ploidy, recruitment, environmental factors, and tamoxifen treatment on the expression of sigma-2 receptors in proliferating and quiescent tumor cells. Br J Cancer 1999; 81:925-933.
Mach RH, Hammond PS, Huang Y, Yang B, Xu Y, Cheney JT, Freeman R, Luedtke RR. Structure-activity relationship studies of N-(9benzyl)-9-azabicyclo-[3.3.1]nonan-3β-yl benzamide analogues for dopamine D2 and D3 receptors. Med Chem Res 1999; 9:355-373.
Gage HD, Gage JC, Chiari A, Xu Z-M, Mach RH, Efange SMN, Ehrenkaufer RLE, Eisenach JC. In vivo imaging of the spinal cord cholinergic system with positron emission tomography. J Comput Assist Tomogr 1999; 23(1):25-33.
Hammond PS, Cheney JT, Johnston DE, Ehrenkaufer RL, Luedtke RR, Mach RH. Synthesis, in vitro dopamine D2 and D3 receptor binding and quantitative structure-activity studies on substituted 2,3-dimethoxy-N-1-benzyl-4-piperidinyl)benzamides and related compounds. Medicinal Chemistry Research 1999; 9:35-49.
Blair JB, Marona-Lewicka D, Kanthasamy A, Lucaites VL, Nelson DL, Nichols DE. Thieno[3,2-b]- and thieno[2,3-b]pyrrole bioisosteric analogues of the hallucinogen and serotonin agonists N,N-dimethyltryptamine. J Med Chem 1999; 42:1106-1111.
Blair JB, Snyder SE, Sherman PS, Kilbourn MR. Synthesis and in vivo characterization of substituted 5-tert-butyl-2-[11C]methyl dithiane oxides as potential radiotracers for the GABAA chloride ion channel. Journal of Labelled Compounds and Radiopharmaceuticals 1999; 42(Suppl 1):S635-S637.
Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE. Effects of ring fluorination on the pharmacology of hallucinogenic tryptamines.
Grant KA, Shively CA, Nader MA, Ehrenkaufer RL, Line SW, Morton TE, Gage HD, Mach RH. The effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography. Synapse 1998; 29:80-83.
Fahey FH, Wood FB, Flowers DL, Eades CG, Gage HD, Harkness BA. Evaluation of brain activation in FDG PET studies. J Comput Assist Tomogr 1998; 22:953-961.
Bastings EP, Gage HD, Greenberg JP, Hammond G, Hernandez L, Santago P, Hamilton CA, Moody DM, Singh KD, Ricci PE, Pons TP, Good DC. Co-registration of cortical magnetic stimulation and functional magnetic resonance imaging. Neuroreport 1998; 9:1941-1946.
Yang B, Johnston DE Jr, Luedtke RR, Hammond PS, Mach RH. Synthesis and in vitro binding of N-alkyl-2,3-dimethoxy[3.3.1]azabicyclononane benzamides at dopamine D2 and D3 receptors. Medicinal Chemistry Research 1998; 8:115-131.
Huang Y, Hammond PS, Whirrett BR, Huhner RJ, Wu L, Childers SR, Mach RH. Synthesis and quantitative structure-activity relationships of N-(1-benzlpiperidin-4-yl)-phenylacetamides and related analogues as potent and selective s1 receptor ligands. J Med Chem 1998; 41:2361-2370.
Bennett BA, Hollingsworth CK, Martin RS, Childers SR, Ehrenkaufer RE, Porrino LJ, Davies HML. Prolonged dopamine and serotonin transporter inhibition after exposure to tropanes. Neuropharmacology 1998; 37:123-130.
Vangveravong S, Kanthasamy A, Lucaites VL, Nichols DE. Synthesis and serotonin receptor affinities of a series of trans-2-(Indol-3-yl)cyclopropylamine derivatives. J Med Chem 1998; 41:4995-5001.
West J, Fitzpatrick M, Wang MY, Dawant BM, Maurer CR Jr, Kessler RM, Maciunas RJ, Barillot C, Lemoine D, Collignon A, Maes F, Suetens P, Vandermeulen D, van den Elsen PA, Napel S, Sumanaweera TS, Harkness B, Hemler PF, Hill DLG, Studholme C, Maintz JBA, Viergever MA, Malandain G, Pennec X, Noz ME, Maguire GQ Jr, Pollack M, Pelizzari CA, Robb RA, Hanson D, Woods RP. Comparison and evaluation of retrospective intermodality image registration techniques. J Comput Assist Tomogr 1997; 21(4):554-566.
Mach RH, Voytko ML, Ehrenkaufer RLE, Nader MA, Tobin JR, Efange SMN, Parsons SM, Gage HD, Smith CR, Morton TE. Imaging of cholinergic terminals using the radiotracer [18F](+)-4-Fluorobenzyltrozamicol: In vitro binding studies and positron emission tomography studies in nonhuman primates. Synapse 1997; 25:368-380.
Mach RH, Nader MA, Ehrenkaufer RLE, Line SW, Smith CR, Gage HD, Morton TE. Use of positron emission tomography to study the dynamics of psychostimulant-induced dopamine release. Pharmacol Biochem Behav 1997; 57:477-486.
Shively CA, Grant KA, Ehrenkaufer RL, Mach RH, Nader MA. Social stress, depression, and brain dopamine in female cynomolgus monkeys. Ann N Y Acad Sci 1997; 807:574-577