Summer Research Opportunities Program 2009

Section on Tumor Biology

Dr. Kazushi Inoue- The project in our laboratory is currently focused on the biological and biochemical characterization of the novel tumor suppressor Dmtf1 (cyclin D binding myb-like transcription factor 1).  Dmtf1 is a critical regulator of the p19^Arf-p53 tumor suppressor pathway.  Dmtf1-knockout mice are prone to tumor development, especially lung carcinomas.  We recently found that the human DMTF1 gene was deleted in 40-50% of human lung and breast cancers.   We have recently identified a few Dmtf1-interacting partners by mass spectrometric analyses.  The summer student will be engaged in molecular characterization of Dmtf1-interacting proteins and their roles in human cancer development.

There are additional 2009 Summer Research Opportunities in the Department of Pathology's Section on Lipid Sciences.